Fibre-type disproportion
Congenital fibre type disproportion (CFTD) is so named because of the characteristic appearance of muscle fibres under a microscope. Muscle tissue has two different types of fibre, type 1 and type 2. In muscle of people affected by CFTD, type 1 fibres are smaller than type 2 fibres, and there are often more type 1 fibres than type 2 fibres. This results in generalised muscle weakness. Progression of CFTD is highly variable and is often determined by genetic background.
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