Oligonucleotide

A short sequence of genetic material (DNA or RNA).

Oculopharyngeal muscular dystrophy

Oculopharyngeal muscular dystrophy(OPMD) is a genetic condition in which there is progressive muscle weakness in the eye and throat muscles. It is caused by a faulty gene (PABP2) and is an autosomal dominant disorder.

Opthalmoplegia

Difficulty in moving the eyes.

Orthoses

Devices or aids to prevent or assist movement of the spine or limbs.

Out of frame mutation

The removal of addition of one or more nucleotides which alters the reading frame, severely affecting the production of the protein e.g. some DMD mutations. Also known as 'frame-shift mutation'. See also In-frame mutation.